SYRE vs VXX: Correlation
How closely do Spyre Therapeutics, Inc. (SYRE) and iPath Series B S&P 500 VIX Short-Term Futures ETN (VXX) trade together? Their weekly returns over three years give a correlation of -0.26, which is negative.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are SYRE and VXX?
Over the past 3 years, SYRE and VXX moved with a correlation of -0.26, which is negative, meaning they tend to move in opposite directions. The past 12 months show a tighter link (-0.11) than the 3-year average (-0.26). Over 5 years the correlation is -0.15, and the annualized covariance of weekly returns is -1350.1 %².
VXX is close to the least connected end of SYRE's tracked universe, ranking #15 of 15. Correlation aside, the last 12 months split them widely, with SYRE ahead by 495.9 points (+446.2% versus -49.7%).
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
SYRE vs VXX: side by side
| SYRE (Spyre Therapeutics, Inc.) | VXX (iPath Series B S&P 500 VIX Short-Term Futures ETN) | |
|---|---|---|
| 1-year return | +446.2% | -49.7% |
| 5-year return | -47.5% | -95.6% |
| Volatility (ann.) | 83.8% | 60.9% |
| Beta vs S&P 500 | 1.80 | -3.31 |
| Max drawdown (3Y) | -74.0% | -83.3% |
| Market cap | $8.3B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 0.00% |
| Sector / category | US Listed | US Listed |
Year-by-year returns
| Year | SYRE | VXX |
|---|---|---|
| 2022 | -90.5% | -23.8% |
| 2023 | +91.3% | -72.5% |
| 2024 | +8.2% | -26.2% |
| 2025 | +40.7% | -42.2% |
| 2026 | +185.8% | -31.6% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are SYRE and VXX good diversifiers for each other?
Yes: at -0.26, the two have gone their own ways historically, which is what genuine diversification looks like.
FAQ
What is the correlation between SYRE and VXX?
Using weekly returns as of 2026-08-27: -0.26 over 3 years, with -0.11 over the last year and -0.15 over 5 years.
Is VXX a good diversifier for SYRE?
Yes: at -0.26, the two have gone their own ways historically, which is what genuine diversification looks like.
What does a correlation of -0.26 mean?
A reading of -0.26 sits on a scale from −1 (opposite moves) through 0 (unrelated) to +1 (identical moves). Correlation captures direction, not magnitude or performance.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/syre-vs-vxx.json
Drop this badge in a README or notebook; it updates with the data:
[](https://www.pairbook.io/pair/syre-vs-vxx/)
Free with attribution; caching and terms are described in the API documentation.
Related comparisons
Hubs: SYRE correlations · VXX correlations
