APGE vs SYRE: Correlation
Measured on weekly returns over the past three years, Apogee Therapeutics, Inc. (APGE) and Spyre Therapeutics, Inc. (SYRE) carry a correlation of 0.48, a moderate link.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are APGE and SYRE?
On 3 years of weekly data the APGE/SYRE correlation comes out at 0.48, moderate. The past 12 months show a weaker link (0.31) than the 3-year average (0.48). The 5-year figure is n/a, and annualized covariance runs at 3337.6 %².
Within APGE's tracked universe of 14 assets, SYRE comes in at #5 by 3-year correlation. Correlation aside, the last 12 months split them widely, with SYRE ahead by 189.1 points (+257.1% versus +446.2%).
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
APGE vs SYRE: side by side
| APGE (Apogee Therapeutics, Inc.) | SYRE (Spyre Therapeutics, Inc.) | |
|---|---|---|
| 1-year return | +257.1% | +446.2% |
| 5-year return | n/a | -47.5% |
| Volatility (ann.) | 82.6% | 83.8% |
| Beta vs S&P 500 | 1.06 | 1.80 |
| Max drawdown (3Y) | -58.8% | -74.0% |
| Market cap | $10.2B | $8.3B |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 0.00% |
| Sector / category | US Listed | US Listed |
Year-by-year returns
| Year | APGE | SYRE |
|---|---|---|
| 2022 | – | -90.5% |
| 2023 | – | +91.3% |
| 2024 | +62.1% | +8.2% |
| 2025 | +66.6% | +40.7% |
| 2026 | +78.8% | +185.8% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are APGE and SYRE good diversifiers for each other?
Reasonably. At 0.48, APGE and SYRE keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
FAQ
What is the correlation between APGE and SYRE?
Using weekly returns as of 2026-08-27: 0.48 over 3 years, with 0.31 over the last year and n/a over 5 years.
Is SYRE a good diversifier for APGE?
Reasonably. At 0.48, APGE and SYRE keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
What does a correlation of 0.48 mean?
On the −1 to +1 scale, 0.48 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/apge-vs-syre.json
Embed this badge (it refreshes with the data), with attribution:
[](https://www.pairbook.io/pair/apge-vs-syre/)
No key needed, free to use. Full endpoint list in the API documentation.
Related comparisons
Hubs: APGE correlations · SYRE correlations
