SYRE vs VVOS: Correlation
Spyre Therapeutics, Inc. (SYRE) and Vivos Therapeutics, Inc. (VVOS) show a moderate relationship: their 3-year correlation of weekly returns is 0.49.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are SYRE and VVOS?
Across a 3-year window, the weekly returns of SYRE and VVOS correlate at 0.49, moderate. Lately the two have drifted apart, with the 1-year correlation at -0.20 versus 0.49 over 3 years. Stretching to 5 years gives 0.19, with an annualized covariance of 9373.1 %².
Few assets follow SYRE as closely as VVOS, which ranks #1 of 15 tracked partners. Correlation aside, the last 12 months split them widely, with SYRE ahead by 540.6 points (+446.2% versus -94.4%). One caveat on sizing: VVOS is 2.7 times as volatile as the other leg, so an equal-dollar split is far from equal-risk.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
SYRE vs VVOS: side by side
| SYRE (Spyre Therapeutics, Inc.) | VVOS (Vivos Therapeutics, Inc.) | |
|---|---|---|
| 1-year return | +446.2% | -94.4% |
| 5-year return | -47.5% | -99.8% |
| Volatility (ann.) | 83.8% | 226.0% |
| Beta vs S&P 500 | 1.80 | 1.24 |
| Max drawdown (3Y) | -74.0% | -99.4% |
| Market cap | $8.3B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 0.00% |
| Sector / category | US Listed | US Listed |
Year-by-year returns
| Year | SYRE | VVOS |
|---|---|---|
| 2022 | -90.5% | -82.1% |
| 2023 | +91.3% | +23.8% |
| 2024 | +8.2% | -65.5% |
| 2025 | +40.7% | -52.7% |
| 2026 | +185.8% | -87.3% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are SYRE and VVOS good diversifiers for each other?
Reasonably. At 0.49, SYRE and VVOS keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
FAQ
What is the correlation between SYRE and VVOS?
As of 2026-08-27, the correlation of weekly returns between SYRE and VVOS is 0.49 over 3 years, -0.20 over 1 year and 0.19 over 5 years.
Is VVOS a good diversifier for SYRE?
Reasonably. At 0.49, SYRE and VVOS keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
What does a correlation of 0.49 mean?
On the −1 to +1 scale, 0.49 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/syre-vs-vvos.json
Drop this badge in a README or notebook; it updates with the data:
[](https://www.pairbook.io/pair/syre-vs-vvos/)
The core API is free. Terms and every endpoint in the API documentation.
Related comparisons
Hubs: SYRE correlations · VVOS correlations
