AGIO vs SPY: Correlation
Measured on weekly returns over the past three years, Agios Pharmaceuticals, Inc. (AGIO) and SPDR S&P 500 ETF Trust (SPY) carry a correlation of 0.41, a moderate link.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are AGIO and SPY?
Over the past 3 years, AGIO and SPY moved with a correlation of 0.41, which is moderate. Little has changed lately, as the 1-year reading of 0.34 lands near the 3-year figure. Over 5 years the correlation is 0.37, and the annualized covariance of weekly returns is 377.1 %².
Within AGIO's tracked universe of 14 assets, SPY comes in at #7 by 3-year correlation. Correlation aside, the last 12 months split them widely, with SPY ahead by 33.3 points (-12.7% versus +20.6%). One caveat on sizing: AGIO is 4.4 times as volatile as the other leg, so an equal-dollar split is far from equal-risk.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
AGIO vs SPY: side by side
| AGIO (Agios Pharmaceuticals, Inc.) | SPY (SPDR S&P 500 ETF Trust) | |
|---|---|---|
| 1-year return | -12.7% | +20.6% |
| 5-year return | -22.1% | +82.4% |
| Volatility (ann.) | 64.3% | 14.5% |
| Beta vs S&P 500 | 1.80 | 1.00 |
| Max drawdown (3Y) | -63.8% | -18.8% |
| Market cap | $2.0B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 1.01% |
| Expense ratio | – | 0.09% |
| Assets under management | – | $795.3B |
| Sector / category | US Listed | ETF · US Large Cap |
SPY is a Large Blend fund from State Street Investment Management: $795.3B under management, 504 holdings, a 0.09% expense ratio, a 1.01% trailing dividend yield.
Year-by-year returns
| Year | AGIO | SPY |
|---|---|---|
| 2022 | -14.6% | -18.2% |
| 2023 | -20.7% | +26.2% |
| 2024 | +47.6% | +24.9% |
| 2025 | -17.2% | +17.7% |
| 2026 | +25.9% | +13.7% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are AGIO and SPY good diversifiers for each other?
A fair diversifier. At 0.41, enough of each asset's movement is its own that the pair has smoothed outcomes historically.
FAQ
What is the correlation between AGIO and SPY?
Using weekly returns as of 2026-08-27: 0.41 over 3 years, with 0.34 over the last year and 0.37 over 5 years.
Is SPY a good diversifier for AGIO?
A fair diversifier. At 0.41, enough of each asset's movement is its own that the pair has smoothed outcomes historically.
What does a correlation of 0.41 mean?
A reading of 0.41 sits on a scale from −1 (opposite moves) through 0 (unrelated) to +1 (identical moves). Correlation captures direction, not magnitude or performance.
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Related comparisons
Hubs: AGIO correlations · SPY correlations
