AGIO vs VXZ: Correlation
How closely do Agios Pharmaceuticals, Inc. (AGIO) and iPath Series B S&P 500 VIX Mid-Term Futures ETN (VXZ) trade together? Their weekly returns over three years give a correlation of -0.37, which is negative.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are AGIO and VXZ?
On 3 years of weekly data the AGIO/VXZ correlation comes out at -0.37, negative, meaning they tend to move in opposite directions. The relationship has been stable: the 1-year correlation (-0.39) sits close to the 3-year figure. The 5-year figure is -0.31, and annualized covariance runs at -616.3 %².
Among the 14 assets we track against AGIO, VXZ sits near the bottom by co-movement, at rank #13. Neither side won the trailing year by much: -12.7% against -16.1%. Risk is not evenly split, since AGIO carries 2.5 times the volatility of the other side.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
AGIO vs VXZ: side by side
| AGIO (Agios Pharmaceuticals, Inc.) | VXZ (iPath Series B S&P 500 VIX Mid-Term Futures ETN) | |
|---|---|---|
| 1-year return | -12.7% | -16.1% |
| 5-year return | -22.1% | -53.1% |
| Volatility (ann.) | 64.3% | 25.6% |
| Beta vs S&P 500 | 1.80 | -1.31 |
| Max drawdown (3Y) | -63.8% | -36.4% |
| Market cap | $2.0B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | – |
| Sector / category | US Listed | US Listed |
Year-by-year returns
| Year | AGIO | VXZ |
|---|---|---|
| 2022 | -14.6% | +0.5% |
| 2023 | -20.7% | -44.0% |
| 2024 | +47.6% | -12.7% |
| 2025 | -17.2% | +5.7% |
| 2026 | +25.9% | -10.5% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are AGIO and VXZ good diversifiers for each other?
Yes: at -0.37, the two have gone their own ways historically, which is what genuine diversification looks like.
FAQ
What is the correlation between AGIO and VXZ?
The AGIO/VXZ correlation stands at -0.37 on a 3-year window (1 year: -0.39, 5 years: -0.31), computed from weekly returns as of 2026-08-27.
Is VXZ a good diversifier for AGIO?
Yes: at -0.37, the two have gone their own ways historically, which is what genuine diversification looks like.
What does a correlation of -0.37 mean?
On the −1 to +1 scale, -0.37 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/agio-vs-vxz.json
Drop this badge in a README or notebook; it updates with the data:
[](https://www.pairbook.io/pair/agio-vs-vxz/)
The core API is free. Terms and every endpoint in the API documentation.
Related comparisons
Hubs: AGIO correlations · VXZ correlations
