SPY vs VTGN: Correlation
SPDR S&P 500 ETF Trust (SPY) and Vistagen Therapeutics, Inc. (VTGN) show a weak relationship: their 3-year correlation of weekly returns is 0.16.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are SPY and VTGN?
Over the past 3 years, SPY and VTGN moved with a correlation of 0.16, which is weak. The link has loosened recently: the 1-year correlation (0.03) runs below the 3-year figure (0.16). Over 5 years the correlation is 0.12, and the annualized covariance of weekly returns is 204.2 %².
By 3-year correlation, VTGN places #3653 of the 4755 assets tracked against SPY. Their recent paths diverged sharply: over the last 12 months SPY outperformed by 112.5 percentage points (+20.6% for SPY against -91.9% for VTGN). One caveat on sizing: VTGN is 6.2 times as volatile as the other leg, so an equal-dollar split is far from equal-risk.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
SPY vs VTGN: side by side
| SPY (SPDR S&P 500 ETF Trust) | VTGN (Vistagen Therapeutics, Inc.) | |
|---|---|---|
| 1-year return | +20.6% | -91.9% |
| 5-year return | +82.4% | -99.7% |
| Volatility (ann.) | 14.5% | 90.2% |
| Beta vs S&P 500 | 1.00 | 0.98 |
| Max drawdown (3Y) | -18.8% | -96.6% |
| Market cap | – | – |
| P/E (trailing) | – | – |
| Dividend yield | 1.01% | 0.00% |
| Expense ratio | 0.09% | – |
| Assets under management | $795.3B | – |
| Sector / category | ETF · US Large Cap | US Listed |
On the fund side, SPY sits in the Large Blend category at State Street Investment Management, with $795.3B under management, 504 holdings, a 0.09% expense ratio, a 1.01% trailing dividend yield.
Year-by-year returns
| Year | SPY | VTGN |
|---|---|---|
| 2022 | -18.2% | -94.9% |
| 2023 | +26.2% | +71.3% |
| 2024 | +24.9% | -42.6% |
| 2025 | +17.7% | -77.6% |
| 2026 | +13.7% | -61.1% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are SPY and VTGN good diversifiers for each other?
Yes. With a correlation of 0.16, SPY and VTGN have moved largely independently, which makes them a genuinely diversifying pair by historical standards.
FAQ
What is the correlation between SPY and VTGN?
The SPY/VTGN correlation stands at 0.16 on a 3-year window (1 year: 0.03, 5 years: 0.12), computed from weekly returns as of 2026-08-27.
Is VTGN a good diversifier for SPY?
Yes. With a correlation of 0.16, SPY and VTGN have moved largely independently, which makes them a genuinely diversifying pair by historical standards.
What does a correlation of 0.16 mean?
On the −1 to +1 scale, 0.16 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/spy-vs-vtgn.json
Embed this badge (it refreshes with the data), with attribution:
[](https://www.pairbook.io/pair/spy-vs-vtgn/)
The core API is free. Terms and every endpoint in the API documentation.
Related comparisons
Hubs: SPY correlations · VTGN correlations
