SPY vs TLSI: Correlation
SPDR S&P 500 ETF Trust (SPY) and TriSalus Life Sciences, Inc. (TLSI) show a weak relationship: their 3-year correlation of weekly returns is 0.18.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are SPY and TLSI?
Across a 3-year window, the weekly returns of SPY and TLSI correlate at 0.18, weak. The past 12 months show a tighter link (0.35) than the 3-year average (0.18). Stretching to 5 years gives 0.12, with an annualized covariance of 236.8 %².
By 3-year correlation, TLSI places #3492 of the 4755 assets tracked against SPY. The last year tells two different stories: SPY led by 23.9 percentage points, +20.6% for SPY against -3.3% for TLSI. Risk is not evenly split, since TLSI carries 6.2 times the volatility of the other side.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
SPY vs TLSI: side by side
| SPY (SPDR S&P 500 ETF Trust) | TLSI (TriSalus Life Sciences, Inc.) | |
|---|---|---|
| 1-year return | +20.6% | -3.3% |
| 5-year return | +82.4% | -49.6% |
| Volatility (ann.) | 14.5% | 89.7% |
| Beta vs S&P 500 | 1.00 | 1.13 |
| Max drawdown (3Y) | -18.8% | -75.4% |
| Market cap | – | $0.3B |
| P/E (trailing) | – | – |
| Dividend yield | 1.01% | 0.00% |
| Expense ratio | 0.09% | – |
| Assets under management | $795.3B | – |
| Sector / category | ETF · US Large Cap | US Listed |
SPY is a Large Blend fund from State Street Investment Management: $795.3B under management, 504 holdings, a 0.09% expense ratio, a 1.01% trailing dividend yield.
Year-by-year returns
| Year | SPY | TLSI |
|---|---|---|
| 2022 | -18.2% | +1.5% |
| 2023 | +26.2% | -15.8% |
| 2024 | +24.9% | -40.7% |
| 2025 | +17.7% | +39.3% |
| 2026 | +13.7% | -29.4% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are SPY and TLSI good diversifiers for each other?
By historical standards, yes. A correlation of 0.18 means the two rarely move for the same reasons.
FAQ
What is the correlation between SPY and TLSI?
As of 2026-08-27, the correlation of weekly returns between SPY and TLSI is 0.18 over 3 years, 0.35 over 1 year and 0.12 over 5 years.
Is TLSI a good diversifier for SPY?
By historical standards, yes. A correlation of 0.18 means the two rarely move for the same reasons.
What does a correlation of 0.18 mean?
A reading of 0.18 sits on a scale from −1 (opposite moves) through 0 (unrelated) to +1 (identical moves). Correlation captures direction, not magnitude or performance.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/spy-vs-tlsi.json
Drop this badge in a README or notebook; it updates with the data:
[](https://www.pairbook.io/pair/spy-vs-tlsi/)
Free with attribution; caching and terms are described in the API documentation.
Related comparisons
Hubs: SPY correlations · TLSI correlations
