OKUR vs SYRE: Correlation
OnKure Therapeutics, Inc. (OKUR) and Spyre Therapeutics, Inc. (SYRE) show a moderate relationship: their 3-year correlation of weekly returns is 0.34.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are OKUR and SYRE?
Over the past 3 years, OKUR and SYRE moved with a correlation of 0.34, which is moderate. The link has loosened recently: the 1-year correlation (0.21) runs below the 3-year figure (0.34). Over 5 years the correlation is 0.17, and the annualized covariance of weekly returns is 2297.5 %².
In OKUR's tracked universe of 15 assets, SYRE sits right near the top at #3. Their recent paths diverged sharply: over the last 12 months SYRE outperformed by 409.4 percentage points (+36.8% for OKUR against +446.2% for SYRE).
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
OKUR vs SYRE: side by side
| OKUR (OnKure Therapeutics, Inc.) | SYRE (Spyre Therapeutics, Inc.) | |
|---|---|---|
| 1-year return | +36.8% | +446.2% |
| 5-year return | -96.0% | -47.5% |
| Volatility (ann.) | 81.5% | 83.8% |
| Beta vs S&P 500 | 0.59 | 1.80 |
| Max drawdown (3Y) | -97.8% | -74.0% |
| Market cap | $0.2B | $8.3B |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 0.00% |
| Sector / category | US Listed | US Listed |
Year-by-year returns
| Year | OKUR | SYRE |
|---|---|---|
| 2022 | -72.7% | -90.5% |
| 2023 | -31.3% | +91.3% |
| 2024 | -46.2% | +8.2% |
| 2025 | -66.3% | +40.7% |
| 2026 | +32.1% | +185.8% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are OKUR and SYRE good diversifiers for each other?
Reasonably. At 0.34, OKUR and SYRE keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
FAQ
What is the correlation between OKUR and SYRE?
As of 2026-08-27, the correlation of weekly returns between OKUR and SYRE is 0.34 over 3 years, 0.21 over 1 year and 0.17 over 5 years.
Is SYRE a good diversifier for OKUR?
Reasonably. At 0.34, OKUR and SYRE keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
What does a correlation of 0.34 mean?
On the −1 to +1 scale, 0.34 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/okur-vs-syre.json
Embed this badge (it refreshes with the data), with attribution:
[](https://www.pairbook.io/pair/okur-vs-syre/)
No key needed, free to use. Full endpoint list in the API documentation.
Related comparisons
Hubs: OKUR correlations · SYRE correlations
