GLUE vs XBI: Correlation
Monte Rosa Therapeutics, Inc. (GLUE) and SPDR S&P Biotech ETF (XBI) show a moderate relationship: their 3-year correlation of weekly returns is 0.53.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are GLUE and XBI?
On 3 years of weekly data the GLUE/XBI correlation comes out at 0.53, moderate. The relationship has been stable: the 1-year correlation (0.46) sits close to the 3-year figure. The 5-year figure is 0.54, and annualized covariance runs at 1520.7 %².
In GLUE's tracked universe of 16 assets, XBI sits right near the top at #1. Correlation aside, the last 12 months split them widely, with GLUE ahead by 119.4 points (+206.6% versus +87.2%). One caveat on sizing: GLUE is 3.8 times as volatile as the other leg, so an equal-dollar split is far from equal-risk.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
GLUE vs XBI: side by side
| GLUE (Monte Rosa Therapeutics, Inc.) | XBI (SPDR S&P Biotech ETF) | |
|---|---|---|
| 1-year return | +206.6% | +87.2% |
| 5-year return | -61.7% | +28.6% |
| Volatility (ann.) | 104.5% | 27.7% |
| Beta vs S&P 500 | 1.91 | 1.09 |
| Max drawdown (3Y) | -64.3% | -33.0% |
| Market cap | $1.2B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | – |
| Sector / category | US Listed | ETF · Thematic |
Year-by-year returns
| Year | GLUE | XBI |
|---|---|---|
| 2022 | -62.7% | -25.9% |
| 2023 | -25.8% | +7.6% |
| 2024 | +22.8% | +1.0% |
| 2025 | +125.9% | +35.9% |
| 2026 | -8.7% | +38.1% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are GLUE and XBI good diversifiers for each other?
Only partially. A correlation of 0.53 means GLUE and XBI share most of their swings. Pairing them dampens volatility somewhat, but it will not protect against a common drawdown.
FAQ
What is the correlation between GLUE and XBI?
As of 2026-08-27, the correlation of weekly returns between GLUE and XBI is 0.53 over 3 years, 0.46 over 1 year and 0.54 over 5 years.
Is XBI a good diversifier for GLUE?
Only partially. A correlation of 0.53 means GLUE and XBI share most of their swings. Pairing them dampens volatility somewhat, but it will not protect against a common drawdown.
What does a correlation of 0.53 mean?
Correlation ranges from −1 to +1. Values near +1 mean two assets move together, near 0 that they move independently, and negative values that they tend to move in opposite directions. It measures co-movement, not performance.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/glue-vs-xbi.json
Embed this badge (it refreshes with the data), with attribution:
[](https://www.pairbook.io/pair/glue-vs-xbi/)
The core API is free. Terms and every endpoint in the API documentation.
Related comparisons
Hubs: GLUE correlations · XBI correlations
