DFTX vs XBI: Correlation
Definium Therapeutics, Inc. (DFTX) and SPDR S&P Biotech ETF (XBI) show a moderate relationship: their 3-year correlation of weekly returns is 0.48.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are DFTX and XBI?
Across a 3-year window, the weekly returns of DFTX and XBI correlate at 0.48, moderate. The past 12 months show a tighter link (0.59) than the 3-year average (0.48). Stretching to 5 years gives 0.43, with an annualized covariance of 1199.5 %².
Within DFTX's tracked universe of 17 assets, XBI comes in at #5 by 3-year correlation. Their recent paths diverged sharply: over the last 12 months DFTX outperformed by 257.7 percentage points (+344.9% for DFTX against +87.2% for XBI). One caveat on sizing: DFTX is 3.3 times as volatile as the other leg, so an equal-dollar split is far from equal-risk.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
DFTX vs XBI: side by side
| DFTX (Definium Therapeutics, Inc.) | XBI (SPDR S&P Biotech ETF) | |
|---|---|---|
| 1-year return | +344.9% | +87.2% |
| 5-year return | +4.7% | +28.6% |
| Volatility (ann.) | 90.9% | 27.7% |
| Beta vs S&P 500 | 1.35 | 1.09 |
| Max drawdown (3Y) | -58.4% | -33.0% |
| Market cap | $5.9B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | – |
| Sector / category | US Listed | ETF · Thematic |
Year-by-year returns
| Year | DFTX | XBI |
|---|---|---|
| 2022 | -89.4% | -25.9% |
| 2023 | +66.4% | +7.6% |
| 2024 | +90.2% | +1.0% |
| 2025 | +92.4% | +35.9% |
| 2026 | +227.3% | +38.1% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are DFTX and XBI good diversifiers for each other?
Reasonably. At 0.48, DFTX and XBI keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
FAQ
What is the correlation between DFTX and XBI?
As of 2026-08-27, the correlation of weekly returns between DFTX and XBI is 0.48 over 3 years, 0.59 over 1 year and 0.43 over 5 years.
Is XBI a good diversifier for DFTX?
Reasonably. At 0.48, DFTX and XBI keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
What does a correlation of 0.48 mean?
A reading of 0.48 sits on a scale from −1 (opposite moves) through 0 (unrelated) to +1 (identical moves). Correlation captures direction, not magnitude or performance.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/dftx-vs-xbi.json
Embed this badge (it refreshes with the data), with attribution:
[](https://www.pairbook.io/pair/dftx-vs-xbi/)
The core API is free. Terms and every endpoint in the API documentation.
Related comparisons
Hubs: DFTX correlations · XBI correlations
