DFTX vs SPY: Correlation
How closely do Definium Therapeutics, Inc. (DFTX) and SPDR S&P 500 ETF Trust (SPY) trade together? Their weekly returns over three years give a correlation of 0.21, which is weak.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are DFTX and SPY?
On 3 years of weekly data the DFTX/SPY correlation comes out at 0.21, weak. Lately the two have drifted apart, with the 1-year correlation at 0.03 versus 0.21 over 3 years. The 5-year figure is 0.33, and annualized covariance runs at 282.0 %².
Among the 17 assets we track against DFTX, SPY sits near the bottom by co-movement, at rank #13. The last year tells two different stories: DFTX led by 324.3 percentage points, +344.9% for DFTX against +20.6% for SPY. Note the risk asymmetry: DFTX runs 6.3 times the annualized volatility of the other leg, so equal-weighting the two is not an equal-risk position.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
DFTX vs SPY: side by side
| DFTX (Definium Therapeutics, Inc.) | SPY (SPDR S&P 500 ETF Trust) | |
|---|---|---|
| 1-year return | +344.9% | +20.6% |
| 5-year return | +4.7% | +82.4% |
| Volatility (ann.) | 90.9% | 14.5% |
| Beta vs S&P 500 | 1.35 | 1.00 |
| Max drawdown (3Y) | -58.4% | -18.8% |
| Market cap | $5.9B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 1.01% |
| Expense ratio | – | 0.09% |
| Assets under management | – | $795.3B |
| Sector / category | US Listed | ETF · US Large Cap |
SPY is a Large Blend fund from State Street Investment Management: $795.3B under management, 504 holdings, a 0.09% expense ratio, a 1.01% trailing dividend yield.
Year-by-year returns
| Year | DFTX | SPY |
|---|---|---|
| 2022 | -89.4% | -18.2% |
| 2023 | +66.4% | +26.2% |
| 2024 | +90.2% | +24.9% |
| 2025 | +92.4% | +17.7% |
| 2026 | +227.3% | +13.7% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are DFTX and SPY good diversifiers for each other?
Yes, to a useful degree: a correlation of 0.21 leaves real independence between the two, which historically damped combined volatility.
FAQ
What is the correlation between DFTX and SPY?
The DFTX/SPY correlation stands at 0.21 on a 3-year window (1 year: 0.03, 5 years: 0.33), computed from weekly returns as of 2026-08-27.
Is SPY a good diversifier for DFTX?
Yes, to a useful degree: a correlation of 0.21 leaves real independence between the two, which historically damped combined volatility.
What does a correlation of 0.21 mean?
On the −1 to +1 scale, 0.21 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
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Hubs: DFTX correlations · SPY correlations
