SOPH vs XBI: Correlation
Measured on weekly returns over the past three years, SOPHiA GENETICS SA (SOPH) and SPDR S&P Biotech ETF (XBI) carry a correlation of 0.39, a moderate link.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are SOPH and XBI?
Across a 3-year window, the weekly returns of SOPH and XBI correlate at 0.39, moderate. Recent behaviour matches the longer record: 0.47 over 1 year against 0.39 over 3. Stretching to 5 years gives 0.37, with an annualized covariance of 655.0 %².
Within SOPH's tracked universe of 11 assets, XBI comes in at #5 by 3-year correlation. Their recent paths diverged sharply: over the last 12 months SOPH outperformed by 80.7 percentage points (+167.9% for SOPH against +87.2% for XBI). Risk is not evenly split, since SOPH carries 2.2 times the volatility of the other side.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
SOPH vs XBI: side by side
| SOPH (SOPHiA GENETICS SA) | XBI (SPDR S&P Biotech ETF) | |
|---|---|---|
| 1-year return | +167.9% | +87.2% |
| 5-year return | -54.1% | +28.6% |
| Volatility (ann.) | 60.0% | 27.7% |
| Beta vs S&P 500 | 1.16 | 1.09 |
| Max drawdown (3Y) | -52.7% | -33.0% |
| Market cap | $0.8B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | – |
| Sector / category | US Listed | ETF · Thematic |
Year-by-year returns
| Year | SOPH | XBI |
|---|---|---|
| 2022 | -85.4% | -25.9% |
| 2023 | +128.6% | +7.6% |
| 2024 | -34.8% | +1.0% |
| 2025 | +52.1% | +35.9% |
| 2026 | +91.0% | +38.1% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are SOPH and XBI good diversifiers for each other?
Yes, to a useful degree: a correlation of 0.39 leaves real independence between the two, which historically damped combined volatility.
FAQ
What is the correlation between SOPH and XBI?
As of 2026-08-27, the correlation of weekly returns between SOPH and XBI is 0.39 over 3 years, 0.47 over 1 year and 0.37 over 5 years.
Is XBI a good diversifier for SOPH?
Yes, to a useful degree: a correlation of 0.39 leaves real independence between the two, which historically damped combined volatility.
What does a correlation of 0.39 mean?
On the −1 to +1 scale, 0.39 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/soph-vs-xbi.json
Embed this badge (it refreshes with the data), with attribution:
[](https://www.pairbook.io/pair/soph-vs-xbi/)
The core API is free. Terms and every endpoint in the API documentation.
Related comparisons
Hubs: SOPH correlations · XBI correlations
