IRON vs XXII: Correlation
Measured on weekly returns over the past three years, Disc Medicine, Inc. (IRON) and 22nd Century Group, Inc (XXII) carry a correlation of -0.18, a negative link.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are IRON and XXII?
Over the past 3 years, IRON and XXII moved with a correlation of -0.18, which is negative, meaning they tend to move in opposite directions. Recent behaviour matches the longer record: -0.21 over 1 year against -0.18 over 3. Over 5 years the correlation is -0.08, and the annualized covariance of weekly returns is -1295.8 %².
Among the 15 assets we track against IRON, XXII ranks #8 by 3-year correlation. Correlation aside, the last 12 months split them widely, with IRON ahead by 137.1 points (+37.7% versus -99.4%). Risk is not evenly split, since XXII carries 2.0 times the volatility of the other side.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
IRON vs XXII: side by side
| IRON (Disc Medicine, Inc.) | XXII (22nd Century Group, Inc) | |
|---|---|---|
| 1-year return | +37.7% | -99.4% |
| 5-year return | -32.4% | -100.0% |
| Volatility (ann.) | 59.7% | 119.0% |
| Beta vs S&P 500 | 1.70 | 2.06 |
| Max drawdown (3Y) | -64.8% | -100.0% |
| Market cap | $3.2B | – |
| P/E (trailing) | – | 0.0 |
| Dividend yield | 0.00% | 0.00% |
| Sector / category | US Listed | US Listed |
Year-by-year returns
| Year | IRON | XXII |
|---|---|---|
| 2022 | -77.2% | -70.2% |
| 2023 | +190.4% | -98.7% |
| 2024 | +9.8% | -98.7% |
| 2025 | +25.3% | -99.4% |
| 2026 | +4.0% | -98.7% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are IRON and XXII good diversifiers for each other?
Yes: at -0.18, the two have gone their own ways historically, which is what genuine diversification looks like.
FAQ
What is the correlation between IRON and XXII?
Using weekly returns as of 2026-08-27: -0.18 over 3 years, with -0.21 over the last year and -0.08 over 5 years.
Is XXII a good diversifier for IRON?
Yes: at -0.18, the two have gone their own ways historically, which is what genuine diversification looks like.
What does a correlation of -0.18 mean?
A reading of -0.18 sits on a scale from −1 (opposite moves) through 0 (unrelated) to +1 (identical moves). Correlation captures direction, not magnitude or performance.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/iron-vs-xxii.json
Drop this badge in a README or notebook; it updates with the data:
[](https://www.pairbook.io/pair/iron-vs-xxii/)
Free with attribution; caching and terms are described in the API documentation.
Related comparisons
Hubs: IRON correlations · XXII correlations
