SNTI vs SPY: Correlation
Measured on weekly returns over the past three years, Senti Biosciences Holdings, Inc. (SNTI) and SPDR S&P 500 ETF Trust (SPY) carry a correlation of 0.21, a weak link.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are SNTI and SPY?
On 3 years of weekly data the SNTI/SPY correlation comes out at 0.21, weak. Little has changed lately, as the 1-year reading of 0.27 lands near the 3-year figure. The 5-year figure is 0.21, and annualized covariance runs at 421.5 %².
Out of 15 assets tracked against SNTI, SPY lands near the bottom at #12. Their recent paths diverged sharply: over the last 12 months SPY outperformed by 96.4 percentage points (-75.8% for SNTI against +20.6% for SPY). Risk is not evenly split, since SNTI carries 9.7 times the volatility of the other side.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
SNTI vs SPY: side by side
| SNTI (Senti Biosciences Holdings, Inc.) | SPY (SPDR S&P 500 ETF Trust) | |
|---|---|---|
| 1-year return | -75.8% | +20.6% |
| 5-year return | -99.6% | +82.4% |
| Volatility (ann.) | 140.6% | 14.5% |
| Beta vs S&P 500 | 2.02 | 1.00 |
| Max drawdown (3Y) | -96.6% | -18.8% |
| Market cap | – | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 1.01% |
| Expense ratio | – | 0.09% |
| Assets under management | – | $795.3B |
| Sector / category | US Listed | ETF · US Large Cap |
SPY is a Large Blend fund from State Street Investment Management: $795.3B under management, 504 holdings, a 0.09% expense ratio, a 1.01% trailing dividend yield.
Year-by-year returns
| Year | SNTI | SPY |
|---|---|---|
| 2022 | -85.7% | -18.2% |
| 2023 | -53.2% | +26.2% |
| 2024 | -46.8% | +24.9% |
| 2025 | -70.4% | +17.7% |
| 2026 | -63.7% | +13.7% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are SNTI and SPY good diversifiers for each other?
Yes, to a useful degree: a correlation of 0.21 leaves real independence between the two, which historically damped combined volatility.
FAQ
What is the correlation between SNTI and SPY?
The SNTI/SPY correlation stands at 0.21 on a 3-year window (1 year: 0.27, 5 years: 0.21), computed from weekly returns as of 2026-08-27.
Is SPY a good diversifier for SNTI?
Yes, to a useful degree: a correlation of 0.21 leaves real independence between the two, which historically damped combined volatility.
What does a correlation of 0.21 mean?
On the −1 to +1 scale, 0.21 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
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Hubs: SNTI correlations · SPY correlations
