SER vs SPY: Correlation
How closely do Serina Therapeutics, Inc. (SER) and SPDR S&P 500 ETF Trust (SPY) trade together? Their weekly returns over three years give a correlation of -0.04, which is near-zero.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are SER and SPY?
On 3 years of weekly data the SER/SPY correlation comes out at -0.04, near zero, meaning they move largely independently. Lately the two have moved closer together, with the 1-year correlation at 0.12 versus -0.04 over 3 years. The 5-year figure is 0.05, and annualized covariance runs at -63.1 %².
By 3-year correlation, SPY places #7 of the 22 assets tracked against SER. Their recent paths diverged sharply: over the last 12 months SPY outperformed by 70.1 percentage points (-49.5% for SER against +20.6% for SPY). One caveat on sizing: SER is 6.8 times as volatile as the other leg, so an equal-dollar split is far from equal-risk.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
SER vs SPY: side by side
| SER (Serina Therapeutics, Inc.) | SPY (SPDR S&P 500 ETF Trust) | |
|---|---|---|
| 1-year return | -49.5% | +20.6% |
| 5-year return | -93.1% | +82.4% |
| Volatility (ann.) | 98.4% | 14.5% |
| Beta vs S&P 500 | -0.30 | 1.00 |
| Max drawdown (3Y) | -95.5% | -18.8% |
| Market cap | $0.1B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 1.01% |
| Expense ratio | – | 0.09% |
| Assets under management | – | $795.3B |
| Sector / category | US Listed | ETF · US Large Cap |
SPY is a Large Blend fund from State Street Investment Management: $795.3B under management, 504 holdings, a 0.09% expense ratio, a 1.01% trailing dividend yield.
Year-by-year returns
| Year | SER | SPY |
|---|---|---|
| 2022 | -49.4% | -18.2% |
| 2023 | -30.3% | +26.2% |
| 2024 | -63.6% | +24.9% |
| 2025 | -61.8% | +17.7% |
| 2026 | +31.7% | +13.7% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are SER and SPY good diversifiers for each other?
Yes: at -0.04, the two have gone their own ways historically, which is what genuine diversification looks like.
FAQ
What is the correlation between SER and SPY?
As of 2026-08-27, the correlation of weekly returns between SER and SPY is -0.04 over 3 years, 0.12 over 1 year and 0.05 over 5 years.
Is SPY a good diversifier for SER?
Yes: at -0.04, the two have gone their own ways historically, which is what genuine diversification looks like.
What does a correlation of -0.04 mean?
A reading of -0.04 sits on a scale from −1 (opposite moves) through 0 (unrelated) to +1 (identical moves). Correlation captures direction, not magnitude or performance.
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Related comparisons
Hubs: SER correlations · SPY correlations
