PRQR vs SPY: Correlation
ProQR Therapeutics N.V. (PRQR) and SPDR S&P 500 ETF Trust (SPY) show a weak relationship: their 3-year correlation of weekly returns is 0.27.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are PRQR and SPY?
On 3 years of weekly data the PRQR/SPY correlation comes out at 0.27, weak. The past 12 months show a tighter link (0.39) than the 3-year average (0.27). The 5-year figure is 0.19, and annualized covariance runs at 414.0 %².
By 3-year correlation, SPY places #16 of the 21 assets tracked against PRQR. Correlation aside, the last 12 months split them widely, with SPY ahead by 15.6 points (+5.0% versus +20.6%). Risk is not evenly split, since PRQR carries 7.2 times the volatility of the other side.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
PRQR vs SPY: side by side
| PRQR (ProQR Therapeutics N.V.) | SPY (SPDR S&P 500 ETF Trust) | |
|---|---|---|
| 1-year return | +5.0% | +20.6% |
| 5-year return | -64.2% | +82.4% |
| Volatility (ann.) | 104.9% | 14.5% |
| Beta vs S&P 500 | 1.98 | 1.00 |
| Max drawdown (3Y) | -75.1% | -18.8% |
| Market cap | $0.3B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 1.01% |
| Expense ratio | – | 0.09% |
| Assets under management | – | $795.3B |
| Sector / category | US Listed | ETF · US Large Cap |
SPY is a Large Blend fund from State Street Investment Management: $795.3B under management, 504 holdings, a 0.09% expense ratio, a 1.01% trailing dividend yield.
Year-by-year returns
| Year | PRQR | SPY |
|---|---|---|
| 2022 | -53.8% | -18.2% |
| 2023 | -46.5% | +26.2% |
| 2024 | +33.8% | +24.9% |
| 2025 | -23.8% | +17.7% |
| 2026 | +14.9% | +13.7% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are PRQR and SPY good diversifiers for each other?
Reasonably. At 0.27, PRQR and SPY keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
FAQ
What is the correlation between PRQR and SPY?
As of 2026-08-27, the correlation of weekly returns between PRQR and SPY is 0.27 over 3 years, 0.39 over 1 year and 0.19 over 5 years.
Is SPY a good diversifier for PRQR?
Reasonably. At 0.27, PRQR and SPY keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
What does a correlation of 0.27 mean?
A reading of 0.27 sits on a scale from −1 (opposite moves) through 0 (unrelated) to +1 (identical moves). Correlation captures direction, not magnitude or performance.
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Related comparisons
Hubs: PRQR correlations · SPY correlations
