OPK vs PYPD: Correlation
Opko Health, Inc. (OPK) and PolyPid Ltd. (PYPD) show a negative relationship: their 3-year correlation of weekly returns is -0.30.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are OPK and PYPD?
Over the past 3 years, OPK and PYPD moved with a correlation of -0.30, which is negative, meaning they tend to move in opposite directions. The link has tightened recently: the 1-year correlation (0.19) runs above the 3-year figure (-0.30). Over 5 years the correlation is -0.09, and the annualized covariance of weekly returns is -1183.9 %².
PYPD is close to the least connected end of OPK's tracked universe, ranking #11 of 11. Correlation aside, the last 12 months split them widely, with PYPD ahead by 44.1 points (+5.6% versus +49.7%). Note the risk asymmetry: PYPD runs 1.7 times the annualized volatility of the other leg, so equal-weighting the two is not an equal-risk position.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
OPK vs PYPD: side by side
| OPK (Opko Health, Inc.) | PYPD (PolyPid Ltd.) | |
|---|---|---|
| 1-year return | +5.6% | +49.7% |
| 5-year return | -60.9% | -98.1% |
| Volatility (ann.) | 48.2% | 81.4% |
| Beta vs S&P 500 | 0.84 | 0.49 |
| Max drawdown (3Y) | -53.2% | -74.1% |
| Market cap | $1.1B | $0.1B |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 0.00% |
| Sector / category | US Listed | US Listed |
Year-by-year returns
| Year | OPK | PYPD |
|---|---|---|
| 2022 | -74.0% | -87.8% |
| 2023 | +20.8% | -81.9% |
| 2024 | -2.6% | -20.0% |
| 2025 | -14.3% | +42.8% |
| 2026 | +19.0% | +18.0% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are OPK and PYPD good diversifiers for each other?
By historical standards, yes. A correlation of -0.30 means the two rarely move for the same reasons.
FAQ
What is the correlation between OPK and PYPD?
The OPK/PYPD correlation stands at -0.30 on a 3-year window (1 year: 0.19, 5 years: -0.09), computed from weekly returns as of 2026-08-27.
Is PYPD a good diversifier for OPK?
By historical standards, yes. A correlation of -0.30 means the two rarely move for the same reasons.
What does a correlation of -0.30 mean?
A reading of -0.30 sits on a scale from −1 (opposite moves) through 0 (unrelated) to +1 (identical moves). Correlation captures direction, not magnitude or performance.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/opk-vs-pypd.json
Markdown for the live badge, attribution link included:
[](https://www.pairbook.io/pair/opk-vs-pypd/)
The core API is free. Terms and every endpoint in the API documentation.
Related comparisons
Hubs: OPK correlations · PYPD correlations
