MLYS vs SPY: Correlation
How closely do Mineralys Therapeutics, Inc. (MLYS) and SPDR S&P 500 ETF Trust (SPY) trade together? Their weekly returns over three years give a correlation of 0.23, which is weak.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are MLYS and SPY?
On 3 years of weekly data the MLYS/SPY correlation comes out at 0.23, weak. The relationship has been stable: the 1-year correlation (0.15) sits close to the 3-year figure. The 5-year figure is n/a, and annualized covariance runs at 321.2 %².
Out of 14 assets tracked against MLYS, SPY lands near the bottom at #10. Their recent paths diverged sharply: over the last 12 months MLYS outperformed by 50.4 percentage points (+71.0% for MLYS against +20.6% for SPY). One caveat on sizing: MLYS is 6.6 times as volatile as the other leg, so an equal-dollar split is far from equal-risk.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
MLYS vs SPY: side by side
| MLYS (Mineralys Therapeutics, Inc.) | SPY (SPDR S&P 500 ETF Trust) | |
|---|---|---|
| 1-year return | +71.0% | +20.6% |
| 5-year return | n/a | +82.4% |
| Volatility (ann.) | 95.4% | 14.5% |
| Beta vs S&P 500 | 1.54 | 1.00 |
| Max drawdown (3Y) | -54.0% | -18.8% |
| Market cap | $2.3B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 1.01% |
| Expense ratio | – | 0.09% |
| Assets under management | – | $795.3B |
| Sector / category | US Listed | ETF · US Large Cap |
SPY is a Large Blend fund from State Street Investment Management: $795.3B under management, 504 holdings, a 0.09% expense ratio, a 1.01% trailing dividend yield.
Year-by-year returns
| Year | MLYS | SPY |
|---|---|---|
| 2022 | – | -18.2% |
| 2023 | – | +26.2% |
| 2024 | +43.1% | +24.9% |
| 2025 | +194.8% | +17.7% |
| 2026 | -28.3% | +13.7% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are MLYS and SPY good diversifiers for each other?
A fair diversifier. At 0.23, enough of each asset's movement is its own that the pair has smoothed outcomes historically.
FAQ
What is the correlation between MLYS and SPY?
The MLYS/SPY correlation stands at 0.23 on a 3-year window (1 year: 0.15, 5 years: n/a), computed from weekly returns as of 2026-08-27.
Is SPY a good diversifier for MLYS?
A fair diversifier. At 0.23, enough of each asset's movement is its own that the pair has smoothed outcomes historically.
What does a correlation of 0.23 mean?
On the −1 to +1 scale, 0.23 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
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Related comparisons
Hubs: MLYS correlations · SPY correlations
