KPTI vs TNON: Correlation
Measured on weekly returns over the past three years, Karyopharm Therapeutics Inc. (KPTI) and Tenon Medical, Inc. (TNON) carry a correlation of -0.32, a negative link.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are KPTI and TNON?
Over the past 3 years, KPTI and TNON moved with a correlation of -0.32, which is negative, meaning they tend to move in opposite directions. The past 12 months show a weaker link (-0.46) than the 3-year average (-0.32). Over 5 years the correlation is -0.28, and the annualized covariance of weekly returns is -94546.8 %².
By 3-year correlation, TNON places #9 of the 18 assets tracked against KPTI. The last year tells two different stories: TNON led by 358.4 percentage points, -75.2% for KPTI against +283.2% for TNON. Risk is not evenly split, since TNON carries 30.8 times the volatility of the other side.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
KPTI vs TNON: side by side
| KPTI (Karyopharm Therapeutics Inc.) | TNON (Tenon Medical, Inc.) | |
|---|---|---|
| 1-year return | -75.2% | +283.2% |
| 5-year return | -97.6% | -99.7% |
| Volatility (ann.) | 98.0% | 3014.0% |
| Beta vs S&P 500 | 1.63 | 4.59 |
| Max drawdown (3Y) | -92.7% | -99.5% |
| Market cap | – | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 0.00% |
| Sector / category | US Listed | US Listed |
Year-by-year returns
| Year | KPTI | TNON |
|---|---|---|
| 2022 | -47.1% | – |
| 2023 | -74.6% | -90.0% |
| 2024 | -21.8% | -85.1% |
| 2025 | -27.4% | -49.4% |
| 2026 | -73.6% | +427.3% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are KPTI and TNON good diversifiers for each other?
Yes: at -0.32, the two have gone their own ways historically, which is what genuine diversification looks like.
FAQ
What is the correlation between KPTI and TNON?
As of 2026-08-27, the correlation of weekly returns between KPTI and TNON is -0.32 over 3 years, -0.46 over 1 year and -0.28 over 5 years.
Is TNON a good diversifier for KPTI?
Yes: at -0.32, the two have gone their own ways historically, which is what genuine diversification looks like.
What does a correlation of -0.32 mean?
On the −1 to +1 scale, -0.32 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/kpti-vs-tnon.json
Drop this badge in a README or notebook; it updates with the data:
[](https://www.pairbook.io/pair/kpti-vs-tnon/)
Free with attribution; caching and terms are described in the API documentation.
Related comparisons
Hubs: KPTI correlations · TNON correlations
