KPTI vs SPY: Correlation
Measured on weekly returns over the past three years, Karyopharm Therapeutics Inc. (KPTI) and SPDR S&P 500 ETF Trust (SPY) carry a correlation of 0.24, a weak link.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are KPTI and SPY?
Over the past 3 years, KPTI and SPY moved with a correlation of 0.24, which is weak. Little has changed lately, as the 1-year reading of 0.20 lands near the 3-year figure. Over 5 years the correlation is 0.26, and the annualized covariance of weekly returns is 340.0 %².
By 3-year correlation, SPY places #6 of the 18 assets tracked against KPTI. The last year tells two different stories: SPY led by 95.8 percentage points, -75.2% for KPTI against +20.6% for SPY. Note the risk asymmetry: KPTI runs 6.8 times the annualized volatility of the other leg, so equal-weighting the two is not an equal-risk position.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
KPTI vs SPY: side by side
| KPTI (Karyopharm Therapeutics Inc.) | SPY (SPDR S&P 500 ETF Trust) | |
|---|---|---|
| 1-year return | -75.2% | +20.6% |
| 5-year return | -97.6% | +82.4% |
| Volatility (ann.) | 98.0% | 14.5% |
| Beta vs S&P 500 | 1.63 | 1.00 |
| Max drawdown (3Y) | -92.7% | -18.8% |
| Market cap | – | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 1.01% |
| Expense ratio | – | 0.09% |
| Assets under management | – | $795.3B |
| Sector / category | US Listed | ETF · US Large Cap |
SPY is a Large Blend fund from State Street Investment Management: $795.3B under management, 504 holdings, a 0.09% expense ratio, a 1.01% trailing dividend yield.
Year-by-year returns
| Year | KPTI | SPY |
|---|---|---|
| 2022 | -47.1% | -18.2% |
| 2023 | -74.6% | +26.2% |
| 2024 | -21.8% | +24.9% |
| 2025 | -27.4% | +17.7% |
| 2026 | -73.6% | +13.7% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are KPTI and SPY good diversifiers for each other?
A fair diversifier. At 0.24, enough of each asset's movement is its own that the pair has smoothed outcomes historically.
FAQ
What is the correlation between KPTI and SPY?
Using weekly returns as of 2026-08-27: 0.24 over 3 years, with 0.20 over the last year and 0.26 over 5 years.
Is SPY a good diversifier for KPTI?
A fair diversifier. At 0.24, enough of each asset's movement is its own that the pair has smoothed outcomes historically.
What does a correlation of 0.24 mean?
Correlation ranges from −1 to +1. Values near +1 mean two assets move together, near 0 that they move independently, and negative values that they tend to move in opposite directions. It measures co-movement, not performance.
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Related comparisons
Hubs: KPTI correlations · SPY correlations
