KPTI vs QQQ: Correlation
How closely do Karyopharm Therapeutics Inc. (KPTI) and Invesco QQQ Trust (QQQ) trade together? Their weekly returns over three years give a correlation of 0.19, which is weak.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are KPTI and QQQ?
On 3 years of weekly data the KPTI/QQQ correlation comes out at 0.19, weak. Recent behaviour matches the longer record: 0.21 over 1 year against 0.19 over 3. The 5-year figure is 0.24, and annualized covariance runs at 369.3 %².
By 3-year correlation, QQQ places #7 of the 18 assets tracked against KPTI. Correlation aside, the last 12 months split them widely, with QQQ ahead by 101.5 points (-75.2% versus +26.3%). Note the risk asymmetry: KPTI runs 5.0 times the annualized volatility of the other leg, so equal-weighting the two is not an equal-risk position.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
KPTI vs QQQ: side by side
| KPTI (Karyopharm Therapeutics Inc.) | QQQ (Invesco QQQ Trust) | |
|---|---|---|
| 1-year return | -75.2% | +26.3% |
| 5-year return | -97.6% | +95.4% |
| Volatility (ann.) | 98.0% | 19.6% |
| Beta vs S&P 500 | 1.63 | 1.28 |
| Max drawdown (3Y) | -92.7% | -22.8% |
| Market cap | – | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 0.44% |
| Expense ratio | – | 0.18% |
| Assets under management | – | $452.8B |
| Sector / category | US Listed | ETF · US Growth & Tech |
QQQ is a Large Growth fund from Invesco: $452.8B under management, 104 holdings, a 0.18% expense ratio, a 0.44% trailing dividend yield.
Year-by-year returns
| Year | KPTI | QQQ |
|---|---|---|
| 2022 | -47.1% | -32.6% |
| 2023 | -74.6% | +54.9% |
| 2024 | -21.8% | +25.6% |
| 2025 | -27.4% | +20.8% |
| 2026 | -73.6% | +17.7% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are KPTI and QQQ good diversifiers for each other?
Yes. With a correlation of 0.19, KPTI and QQQ have moved largely independently, which makes them a genuinely diversifying pair by historical standards.
FAQ
What is the correlation between KPTI and QQQ?
The KPTI/QQQ correlation stands at 0.19 on a 3-year window (1 year: 0.21, 5 years: 0.24), computed from weekly returns as of 2026-08-27.
Is QQQ a good diversifier for KPTI?
Yes. With a correlation of 0.19, KPTI and QQQ have moved largely independently, which makes them a genuinely diversifying pair by historical standards.
What does a correlation of 0.19 mean?
Correlation ranges from −1 to +1. Values near +1 mean two assets move together, near 0 that they move independently, and negative values that they tend to move in opposite directions. It measures co-movement, not performance.
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Related comparisons
Hubs: KPTI correlations · QQQ correlations
