HSIC vs XLO: Correlation
Henry Schein (HSIC) and Xilio Therapeutics, Inc. (XLO) show a negative relationship: their 3-year correlation of weekly returns is -0.19.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are HSIC and XLO?
Across a 3-year window, the weekly returns of HSIC and XLO correlate at -0.19, negative, meaning they tend to move in opposite directions. The past 12 months show a tighter link (0.02) than the 3-year average (-0.19). Stretching to 5 years gives 0.00, with an annualized covariance of -464.0 %².
Within HSIC's tracked universe of 34 assets, XLO comes in at #29 by 3-year correlation. Correlation aside, the last 12 months split them widely, with HSIC ahead by 36.9 points (+30.9% versus -6.0%). Risk is not evenly split, since XLO carries 3.8 times the volatility of the other side.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
HSIC vs XLO: side by side
| HSIC (Henry Schein) | XLO (Xilio Therapeutics, Inc.) | |
|---|---|---|
| 1-year return | +30.9% | -6.0% |
| 5-year return | +20.1% | -96.0% |
| Volatility (ann.) | 25.2% | 96.4% |
| Beta vs S&P 500 | 0.33 | -0.07 |
| Max drawdown (3Y) | -24.3% | -82.8% |
| Market cap | $10.1B | $0.1B |
| P/E (trailing) | 26.3 | – |
| Dividend yield | 0.00% | 0.00% |
| Sector / category | Health Care | US Listed |
Year-by-year returns
| Year | HSIC | XLO |
|---|---|---|
| 2022 | +3.0% | -83.2% |
| 2023 | -5.2% | -79.6% |
| 2024 | -8.6% | +73.6% |
| 2025 | +9.2% | -33.0% |
| 2026 | +19.4% | +0.6% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are HSIC and XLO good diversifiers for each other?
Yes. With a correlation of -0.19, HSIC and XLO have moved largely independently, which makes them a genuinely diversifying pair by historical standards.
FAQ
What is the correlation between HSIC and XLO?
Using weekly returns as of 2026-08-27: -0.19 over 3 years, with 0.02 over the last year and 0.00 over 5 years.
Is XLO a good diversifier for HSIC?
Yes. With a correlation of -0.19, HSIC and XLO have moved largely independently, which makes them a genuinely diversifying pair by historical standards.
What does a correlation of -0.19 mean?
On the −1 to +1 scale, -0.19 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/hsic-vs-xlo.json
Markdown for the live badge, attribution link included:
[](https://www.pairbook.io/pair/hsic-vs-xlo/)
The core API is free. Terms and every endpoint in the API documentation.
Related comparisons
Hubs: HSIC correlations · XLO correlations
