DNLI vs VRTX: Correlation
How closely do Denali Therapeutics Inc. (DNLI) and Vertex Pharmaceuticals (VRTX) trade together? Their weekly returns over three years give a correlation of 0.39, which is moderate.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are DNLI and VRTX?
Over the past 3 years, DNLI and VRTX moved with a correlation of 0.39, which is moderate. Little has changed lately, as the 1-year reading of 0.47 lands near the 3-year figure. Over 5 years the correlation is 0.37, and the annualized covariance of weekly returns is 723.1 %².
Out of 25 assets tracked against DNLI, VRTX lands near the bottom at #21. Correlation aside, the last 12 months split them widely, with DNLI ahead by 17.4 points (+58.1% versus +40.7%). Note the risk asymmetry: DNLI runs 2.0 times the annualized volatility of the other leg, so equal-weighting the two is not an equal-risk position.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
DNLI vs VRTX: side by side
| DNLI (Denali Therapeutics Inc.) | VRTX (Vertex Pharmaceuticals) | |
|---|---|---|
| 1-year return | +58.1% | +40.7% |
| 5-year return | -53.4% | +174.5% |
| Volatility (ann.) | 60.6% | 30.3% |
| Beta vs S&P 500 | 2.02 | 0.55 |
| Max drawdown (3Y) | -63.7% | -29.1% |
| Market cap | $3.9B | $138.8B |
| P/E (trailing) | – | 31.9 |
| Dividend yield | 0.00% | 0.00% |
| Sector / category | US Listed | Health Care |
Year-by-year returns
| Year | DNLI | VRTX |
|---|---|---|
| 2022 | -37.6% | +31.5% |
| 2023 | -22.8% | +40.9% |
| 2024 | -5.0% | -1.0% |
| 2025 | -19.0% | +12.6% |
| 2026 | +49.4% | +20.8% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are DNLI and VRTX good diversifiers for each other?
Reasonably. At 0.39, DNLI and VRTX keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
FAQ
What is the correlation between DNLI and VRTX?
Using weekly returns as of 2026-08-27: 0.39 over 3 years, with 0.47 over the last year and 0.37 over 5 years.
Is VRTX a good diversifier for DNLI?
Reasonably. At 0.39, DNLI and VRTX keep a meaningful degree of independence, and combining them has historically reduced portfolio volatility.
What does a correlation of 0.39 mean?
Correlation ranges from −1 to +1. Values near +1 mean two assets move together, near 0 that they move independently, and negative values that they tend to move in opposite directions. It measures co-movement, not performance.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/dnli-vs-vrtx.json
Markdown for the live badge, attribution link included:
[](https://www.pairbook.io/pair/dnli-vs-vrtx/)
The core API is free. Terms and every endpoint in the API documentation.
Related comparisons
Hubs: DNLI correlations · VRTX correlations
