CYRX vs SPY: Correlation
Measured on weekly returns over the past three years, CryoPort, Inc. (CYRX) and SPDR S&P 500 ETF Trust (SPY) carry a correlation of 0.33, a moderate link.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are CYRX and SPY?
Across a 3-year window, the weekly returns of CYRX and SPY correlate at 0.33, moderate. Little has changed lately, as the 1-year reading of 0.36 lands near the 3-year figure. Stretching to 5 years gives 0.48, with an annualized covariance of 301.0 %².
Among the 14 assets we track against CYRX, SPY ranks #9 by 3-year correlation. The last year tells two different stories: CYRX led by 68.3 percentage points, +88.9% for CYRX against +20.6% for SPY. One caveat on sizing: CYRX is 4.3 times as volatile as the other leg, so an equal-dollar split is far from equal-risk.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
CYRX vs SPY: side by side
| CYRX (CryoPort, Inc.) | SPY (SPDR S&P 500 ETF Trust) | |
|---|---|---|
| 1-year return | +88.9% | +20.6% |
| 5-year return | -73.7% | +82.4% |
| Volatility (ann.) | 62.3% | 14.5% |
| Beta vs S&P 500 | 1.44 | 1.00 |
| Max drawdown (3Y) | -75.0% | -18.8% |
| Market cap | $0.8B | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 1.01% |
| Expense ratio | – | 0.09% |
| Assets under management | – | $795.3B |
| Sector / category | US Listed | ETF · US Large Cap |
SPY is a Large Blend fund from State Street Investment Management: $795.3B under management, 504 holdings, a 0.09% expense ratio, a 1.01% trailing dividend yield.
Year-by-year returns
| Year | CYRX | SPY |
|---|---|---|
| 2022 | -70.7% | -18.2% |
| 2023 | -10.7% | +26.2% |
| 2024 | -49.8% | +24.9% |
| 2025 | +23.4% | +17.7% |
| 2026 | +72.6% | +13.7% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are CYRX and SPY good diversifiers for each other?
A fair diversifier. At 0.33, enough of each asset's movement is its own that the pair has smoothed outcomes historically.
FAQ
What is the correlation between CYRX and SPY?
As of 2026-08-27, the correlation of weekly returns between CYRX and SPY is 0.33 over 3 years, 0.36 over 1 year and 0.48 over 5 years.
Is SPY a good diversifier for CYRX?
A fair diversifier. At 0.33, enough of each asset's movement is its own that the pair has smoothed outcomes historically.
What does a correlation of 0.33 mean?
On the −1 to +1 scale, 0.33 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
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Related comparisons
Hubs: CYRX correlations · SPY correlations
