CYCN vs LPCN: Correlation
Cyclerion Therapeutics, Inc. (CYCN) and Lipocine Inc. (LPCN) show a negative relationship: their 3-year correlation of weekly returns is -0.37.
Data as of 2026-08-27 · refreshed every trading day · weekly returns · methodology
How correlated are CYCN and LPCN?
On 3 years of weekly data the CYCN/LPCN correlation comes out at -0.37, negative, meaning they tend to move in opposite directions. Lately the two have drifted apart, with the 1-year correlation at -0.62 versus -0.37 over 3 years. The 5-year figure is -0.27, and annualized covariance runs at -6926.9 %².
LPCN is close to the least connected end of CYCN's tracked universe, ranking #21 of 21. Correlation aside, the last 12 months split them widely, with CYCN ahead by 81.2 points (+55.3% versus -25.9%). Note the risk asymmetry: CYCN runs 2.3 times the annualized volatility of the other leg, so equal-weighting the two is not an equal-risk position.
How is this computed?
Pearson correlation on weekly returns: ρ(A,B) = cov(rA, rB) / (σA · σB), over windows of 52, 156 and 260 weeks. Covariance is annualized (×52) and expressed in %². Full definitions on the methodology page.
CYCN vs LPCN: side by side
| CYCN (Cyclerion Therapeutics, Inc.) | LPCN (Lipocine Inc.) | |
|---|---|---|
| 1-year return | +55.3% | -25.9% |
| 5-year return | -93.7% | -90.3% |
| Volatility (ann.) | 208.6% | 90.4% |
| Beta vs S&P 500 | 1.03 | 0.69 |
| Max drawdown (3Y) | -83.0% | -82.8% |
| Market cap | – | – |
| P/E (trailing) | – | – |
| Dividend yield | 0.00% | 0.00% |
| Sector / category | US Listed | US Listed |
Year-by-year returns
| Year | CYCN | LPCN |
|---|---|---|
| 2022 | -61.9% | -59.8% |
| 2023 | -74.5% | -58.8% |
| 2024 | -3.9% | +74.9% |
| 2025 | -60.6% | +64.5% |
| 2026 | +214.2% | -72.2% |
Calendar-year price returns; the current year is year-to-date as of the data date above.
Are CYCN and LPCN good diversifiers for each other?
By historical standards, yes. A correlation of -0.37 means the two rarely move for the same reasons.
FAQ
What is the correlation between CYCN and LPCN?
Using weekly returns as of 2026-08-27: -0.37 over 3 years, with -0.62 over the last year and -0.27 over 5 years.
Is LPCN a good diversifier for CYCN?
By historical standards, yes. A correlation of -0.37 means the two rarely move for the same reasons.
What does a correlation of -0.37 mean?
On the −1 to +1 scale, -0.37 describes how much the two returns move together: +1 is lockstep, 0 is independence, negative values mean opposite directions. It says nothing about which performed better.
Use this data
$ curl https://www.pairbook.io/api/v1/pairs/cycn-vs-lpcn.json
Embed this badge (it refreshes with the data), with attribution:
[](https://www.pairbook.io/pair/cycn-vs-lpcn/)
The core API is free. Terms and every endpoint in the API documentation.
Related comparisons
Hubs: CYCN correlations · LPCN correlations
